We are looking for enthusiastic and ambitious students who are keen to work on the functional omics of ageing and age-related diseases as part of their PhD.
The job holder will be part of the Population Health Sciences group, led by Prof Dr Monique M B Breteler, and located at the headquarters of the German Center for Neurodegenerative Diseases (DZNE) in Bonn. We study causes and biomarkers of normal and pathological mental and physical health, with a special emphasis on neurodegenerative diseases and ageing. The research is primarily based on the Rhineland Study, a prospective cohort study that emphasizes deep phenotyping. The study currently includes more than 11.000 participants at baseline, follow-up data is already available from nearly 5000 participants, and further data collection is ongoing. Available clinical data include detailed structural and functional brain imaging, cognitive and neurological assessments, cardiovascular and anthropometric assessments, sensory systems tests, medical history, and medication use. We further have detailed exposome data, including information on physical activity, diet, and environmental toxin and temperature exposure. Importantly, we have extensive multi-omics data, both from baseline and follow-up, including genomic and epigenomic data (miRNA sequencing, DNA-methylation), transcriptomics, metabolomics, lipidomics and proteomics data.